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Combinatorial Solid-Phase Synthesis of 6-Hydroxy-1,2,3,4-tetrahydro-β-carbolines from l -5-Hydroxytryptophan

✍ Scribed by Danieli, Bruno; Giovanelli, Paola; Lesma, Giordano; Passarella, Daniele; Sacchetti, Alessandro; Silvani, Alessandra


Book ID
121303542
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
117 KB
Volume
7
Category
Article
ISSN
1520-4766

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Synthesis of Functionalized 1,2,3,4-Tetr
✍ Tietze, Lutz F. ;Wichmann, Jürgen 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 614 KB

## Abstract Reaction of tryptamine (1) with 2 and 3 gives the enamino ketones 4a and 5, resp., which on treatment with trifluoroacetic acid lead to the 2‐substituted indoles 8 and 9, respectively. Acylation of 4a followed by reaction with trifluoroacetic acid or a Lewis acid affords the 1,2,3,4‐tet