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Solid-Phase Peptide Synthesis in the Reverse ( N → C ) Direction

✍ Scribed by Thieriet, Nathalie; Guibé, François; Albericio, Fernando


Book ID
126828147
Publisher
American Chemical Society
Year
2000
Tongue
English
Weight
46 KB
Volume
2
Category
Article
ISSN
1523-7060

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Investigations on Solid-Phase Peptide Sy
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A new silyl linker for reverse-direction
✍ Bruce H Lipshutz; Young-Jun Shin 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 249 KB

Treatment of a free amino acid ester with CO 2 followed by exposure to a chlorosilane-containing polystyrene results in its attachment to the solid support. The newly formed silyl carbamate can be employed to build polypeptides at the carboxyl terminus. Cleavage of the (poly)peptide using aqueous HF