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Solid-Phase Organic Synthesis of Polyisoprenoid Alcohols with Traceless Sulfone Linker

✍ Scribed by Chang, Yi-Fan; Liu, Chen-Yu; Guo, Chih-Wei; Wang, Yen-Chih; Fang, Jim-Min; Cheng, Wei-Chieh


Book ID
124154330
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
732 KB
Volume
73
Category
Article
ISSN
0022-3263

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πŸ“œ SIMILAR VOLUMES


A photolabile β€˜traceless’ linker for sol
✍ James R Horton; Louise M Stamp; Anne Routledge πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 French βš– 75 KB

A photolabile linker based on a thiohydroxamic acid has been shown to be an efficient 'traceless' linker, revealing an aliphatic CH bond on photolysis at 350 nm. Methods for the synthesis, loading and photolytic cleavage of the linker are described.

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Traceless linkers, which enable the attachment of arenes and alkanes to a polymeric support, have received increased attention in recent years. These anchoring groups allow chemical transformations on the polymer-bound molecules, which can be cleaved from the resin leaving no residual functionality