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Solid phase insertion of diamines into peptide chains

✍ Scribed by Manolis Karavoltsos; Spyros Mourtas; Dimitrios Gatos; Kleomenis Barlos

Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 281 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(03)00708-1

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✦ Synopsis

Diamines derived from naturally occurring aminoacids were inserted into peptide chains by the reaction of the monophthaloyl diamines with amino acid 1-benzotriazolyl esters, bound through their amino functions onto trityl-type resins. The phthaloyl group was removed and peptide chains using N-Fmoc amino acids, were assembled on the liberated amino function. The peptidyl diamides obtained, were cleaved from the resins with t Bu-side chain protection remaining intact, or fully deprotected.

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