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Solid phase chemistry approach to the SAR development of a novel class of active site-directed thrombin inhibitors

✍ Scribed by Mary George Johnson; Duane D. Bronson; Jan E. Gillespie; Donetta S. Gifford-Moore; Kyomi Kalter; Michael P. Lynch; Jefferson R. McCowan; Catherine C. Redick; Daniel J. Sall; Gerald F. Smith; Robert J. Foglesong

Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 699 KB
Volume: 55
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(99)00684-5

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✦ Synopsis

A solid phase chemistry approach utilizing Mitsunobu chemistry, amine functionalization, and parallel purification was used to produce a diverse library of benzothiophene analogs. These analogs were used to advance the SAR of this class of molecules and give new directions for future studies.

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