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Development of a Solid-Phase Approach to the Natural Product Class of Ahp-Containing Cyclodepsipeptides

โœ Scribed by Sara C. Stolze; Michael Meltzer; Michael Ehrmann; Markus Kaiser


Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
765 KB
Volume
2012
Category
Article
ISSN
1434-193X

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Solid phase chemistry approach to the SA
โœ Mary George Johnson; Duane D. Bronson; Jan E. Gillespie; Donetta S. Gifford-Moor ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 699 KB

A solid phase chemistry approach utilizing Mitsunobu chemistry, amine functionalization, and parallel purification was used to produce a diverse library of benzothiophene analogs. These analogs were used to advance the SAR of this class of molecules and give new directions for future studies.