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Design of a novel class of bifunctional thrombin inhibitors, synthesised by the first application of peptide boronates in solid phase chemistry

โœ Scribed by Said Elgendy; Geeta Patel; Donovan Green; Christopher A. Goodwin; Michael F. Scully; Wahid Husman; Emmanuel Skordalakes; Vijay V. Kakkar; John J. Deadman


Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
221 KB
Volume
38
Category
Article
ISSN
0040-4039

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โœ Mary George Johnson; Duane D. Bronson; Jan E. Gillespie; Donetta S. Gifford-Moor ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 699 KB

A solid phase chemistry approach utilizing Mitsunobu chemistry, amine functionalization, and parallel purification was used to produce a diverse library of benzothiophene analogs. These analogs were used to advance the SAR of this class of molecules and give new directions for future studies.