Solid-Phase Chemical Synthesis of Phosphonoacetate and Thiophosphonoacetate Oligodeoxynucleotides
✍ Scribed by Dellinger, Douglas J.; Sheehan, David M.; Christensen, Nanna K.; Lindberg, James G.; Caruthers, Marvin H.
- Book ID
- 111899474
- Publisher
- American Chemical Society
- Year
- 2003
- Tongue
- English
- Weight
- 196 KB
- Volume
- 125
- Category
- Article
- ISSN
- 0002-7863
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
A galactose-modified deoxyuridine phosphoramidite was synthesized via the Heck reaction and applied to solid-phase synthesis to provide a new type of oligo DNA-galactose conjugates, which maintained stringent base-pairing fidelity for unique DNA sequences.
## Abstract Immobilized and fully protected oligodeoxynucleotides containing a 4‐(1,2,4‐triazolyl)‐thymidine residue at a predetermined position were prepared according to a well‐established phosphite triester methodology using 2‐cyanoethyl phosphoramidites of a 4‐(1,2,4‐triazolyl)‐substituted thym
## Abstract High‐quality oligodeoxynucleotides having an 6‐__O__‐alkyl‐2′‐deoxyguanosine (alkyl = methyl, ethyl, __n__‐propyl or __n__‐hexyl) residue at a predetermined position can be obtained via a solid‐phase approach using the respective 2‐cyanoethyl __N,N__‐diisopropylphosphoramidites of 5′‐__