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Smoking interacts withHLA-DRB1shared epitope in the development of anti-citrullinated protein antibody-positive rheumatoid arthritis: results from the Malaysian Epidemiological Investigation of Rheumatoid Arthritis (MyEIRA)

✍ Scribed by Chun Lai Too, Abqariyah Yahya, Shahnaz Murad…

Book ID: 120706103
Publisher: BioMed Central
Year: 2012
Tongue: English
Weight: 242 KB
Volume: 14
Category: Article
ISSN: 1478-6354
DOI: 10.1186/ar3813

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## Abstract ## Objective The shared epitope (SE)–containing HLA–DRB1 alleles represent the most significant genetic risk factor for rheumatoid arthritis (RA). Recent studies indicate that the SE alleles are associated with only RA that is characterized by the presence of anti–cyclic citrullinated