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Small Ring Constrained Peptidomimetics. Synthesis of Epoxy Peptidomimetics, Inhibitors of Cysteine Proteases

โœ Scribed by Demarcus, Mariangela; Ganadu, Maria Luisa; Mura, Giovanni Maria; Porcheddu, Andrea; Quaranta, Laura; Reginato, Gianna; Taddei, Maurizio


Book ID
126298354
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
134 KB
Volume
66
Category
Article
ISSN
0022-3263

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Small ring constrained peptidomimetics.
โœ Silvia N. Filigheddu; Maurizio Taddei ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 194 KB

The synthesis of a series of novel amino acids and peptides containing an aziridine ring is described. Their preparation is based on the Gabriel-CromweU reaction of amino acids or peptides with different 2-bromo acrylates and acrylamides. These products are constituted by a turned scaffold (the azir