A series of appended macrocycles were synthesized and tested as inhibitors of HIV-1 protease (HIV PR). The macrocycle structurally mimics an N-terminal tripeptide component of peptide substrates. Structure-activity relationships explore steric limitations to the size and shape of the substituents an
Design of small peptidomimetic HIV-1 protease inhibitors and prodrug forms
β Scribed by Yoshiaki Kiso; Hikaru Matsumoto; Satoshi Yamaguchi; Tooru Kimura
- Publisher
- Springer Netherlands
- Year
- 1999
- Tongue
- English
- Weight
- 511 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1573-3149
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