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Small ring constrained peptidomimetics. Synthesis of aziridine parallel β-sheet mimetics

✍ Scribed by Silvia N. Filigheddu; Maurizio Taddei

Book ID
104259240
Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
194 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

The synthesis of a series of novel amino acids and peptides containing an aziridine ring is described. Their preparation is based on the Gabriel-CromweU reaction of amino acids or peptides with different 2-bromo acrylates and acrylamides. These products are constituted by a turned scaffold (the aziridine) where two parallel peptidic strands can be grown to produce a I]-sheet mimetic.

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