ChemInform Abstract: Combinatorial Biomimetic Chemistry: Parallel Synthesis of a Small Library of β-Hairpin Mimetics Based on Loop III from Human Platelet-Derived Growth Factor B.

Combinatorial Biomimetic Chemistry: Para

Combinatorial Biomimetic Chemistry: Parallel Synthesis of a Small Library of β-Hairpin Mimetics Based on Loop III from Human Platelet-Derived Growth Factor B

✍ Lujong Jiang; Kerstin Moehle; Boopathy Dhanapal; Daniel Obrecht; John A. Robinso 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 German ⚖ 283 KB 👁 1 views

Combinatorial diversity in hypervariable b-hairpin loops is exploited by the immune system to select binding sites on antibodies for a wide variety of different protein antigens. In a first step towards mimicking this strategy in vitro, for the selection of novel protein ligands, an approach is desc