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Smad6 inhibits signalling by the TGF-β superfamily

✍ Scribed by Kawabata, Masahiro; Imamura, Takeshi; Takase, Masao; Nishihara, Ayako; Oeda, Eiichi; Hanai, Jun-ichi; Miyazono, Kohei

Book ID
118675192
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
523 KB
Volume
389
Category
Article
ISSN
0028-0836

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Members of the transforming growth factor‐β (TGF‐β) superfamily bind to two different serine/threonine kinase receptors, i.e. type I and type II receptors. Upon ligand binding, type I receptors specifically activate intracellular Smad proteins. R‐Smads are direct substrates of type I receptors; Smad