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The regulation of TGF-β/SMAD signaling by protein deubiquitination

✍ Scribed by Zhang, Juan; Zhang, Xiaofei; Xie, Feng; Zhang, Zhengkui; van Dam, Hans; Zhang, Long; Zhou, Fangfang

Book ID
125383922
Publisher
SP Higher Education Press
Year
2014
Tongue
English
Weight
526 KB
Volume
5
Category
Article
ISSN
1674-800X

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TGFbeta inducible early gene (TIEG) is a novel Krüppel-like transcriptional repressor that was recently shown to increase the activity of the TGFbeta/Smad signal transduction pathway by relieving negative feedback through repression of the inhibitory Smad7. Interestingly, while Smad7 is required for