SMAD7 is a prognostic marker in patients
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Jean-Louis Boulay; Gabriele Mild; Adam Lowy; Juergen Reuter; Magali Lagrange; Lu
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Article
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2003
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John Wiley and Sons
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French
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## Abstract Chromosomal region 18q21 is frequently deleted in colorectal cancer (CRC) and is associated with poor prognosis. Potential tumor suppressor mechanisms altered by 18q21 deletion include mediation of TGFΞ² signaling by SMADs. Following the definition of __SMAD4__ deletion as a negative pre