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Skipping Cancer: Small Molecule Inhibitors of SKP2-Mediated p27 Degradation

✍ Scribed by Elizabeth Rico-Bautista; Dieter A. Wolf


Book ID
118174325
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
194 KB
Volume
19
Category
Article
ISSN
1074-5521

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p27(Kip1), an important regulator of Cdk2 activity and G 1 /S transition, is tightly regulated in a cell-type and condition-specific manner to integrate mitogenic and differentiation signals governing cell cycle progression. We show that p27 protein levels progressively declined from mid-G 1 through