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Skp2-mediated degradation of p27 regulates cell cycle progression in compressed human bladder smooth muscle cells

โœ Scribed by Chen, Lin; Wu, Tao; Wei, Tang-Qiang; Wei, Xin; Li, Sheng-Fu; Wang, Kun-Jie; Li, Hong


Book ID
123197350
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
763 KB
Volume
30
Category
Article
ISSN
0257-5655

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## Background: The cyclin-dependent kinase inhibitor p27 is a putative tumor suppressor that is downregulated in the majority of human prostate cancers. the mechanism of p27 down-regulation in prostate cancers in unknown, but presumably involves increased proteolysis mediated by the scfskp2 ubiquit