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Downregulation of cyclin-dependent kinase inhibitor; p57kip2, is involved in the cell cycle progression of vascular smooth muscle cells

โœ Scribed by Noritsugu Nakano; Kazushi Urasawa; Yasushi Takagi; Takahiko Saito; Satoshi Kaneta; Susumu Ishikawa; Hideaki Higashi; Hiroyuki Tsutsui; Masanori Hatakeyama; Akira Kitabatake


Book ID
116291683
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
314 KB
Volume
338
Category
Article
ISSN
0006-291X

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## Abstract Chronic oxidative injury by allylamine (AAM) induces proliferative vascular smooth muscle cell (vSMC) phenotypes in the rat aorta similar to those seen in rodent and human atherosclerotic lesions. The proliferative advantage of AAM vSMC compared to control cells is maintained with seria