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Skp2-Mediated Degradation of p27 Regulates Progression into Mitosis

✍ Scribed by Keiko Nakayama; Hiroyasu Nagahama; Yohji A Minamishima; Satoshi Miyake; Noriko Ishida; Shigetsugu Hatakeyama; Masatoshi Kitagawa; Shun-ichiro Iemura; Tohru Natsume; Keiichi I Nakayama

Book ID
117795548
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
951 KB
Volume
6
Category
Article
ISSN
1534-5807

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✍ Corinth A. Auld; Karishma M. Fernandes; Ron F. Morrison πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 473 KB

p27(Kip1), an important regulator of Cdk2 activity and G 1 /S transition, is tightly regulated in a cell-type and condition-specific manner to integrate mitogenic and differentiation signals governing cell cycle progression. We show that p27 protein levels progressively declined from mid-G 1 through