## Abstract In this study, the mutation frequencies of the p53 gene in rat hepatocellular carcinomas (HCCs) induced by __N__โnitrosoโ2โacetylaminofluorene (NOโAAF) and 2โacetylaminofluorene (AAF) were 19.23% (20 of 104) and 31.1% (33 of 106), respectively. Four noteworthy features of the mutation s
โฆ LIBER โฆ
Skin Tumours and Sarcomata induced in Rats by N-Hydroxy-2-acetylaminofluorene
โ Scribed by GOODALL, C. M.; GASTEYER, S.
- Book ID
- 109652231
- Publisher
- Nature Publishing Group
- Year
- 1966
- Tongue
- English
- Weight
- 137 KB
- Volume
- 211
- Category
- Article
- ISSN
- 0028-0836
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In a previous study, we found that treating transgenic Big Blue rats with the hepatocarcinogen N-hydroxy-2-acetylaminofluorene (N-OH-AAF) produced the same major DNA adduct in the target liver and the nontarget spleen lymphocytes and bone marrow cells, induced lacI mutants in the liver, and induced