Bioactivation of the hepatocarcinogen N-hydroxy-2-acetylaminofluorene by sulfation in the rat liver changes during the cell cycle
โ Scribed by Ron A.H.J. Gilissen; John H.N. Meerman
- Book ID
- 118345221
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 386 KB
- Volume
- 51
- Category
- Article
- ISSN
- 0024-3205
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In a previous study, we found that treating transgenic Big Blue rats with the hepatocarcinogen N-hydroxy-2-acetylaminofluorene (N-OH-AAF) produced the same major DNA adduct in the target liver and the nontarget spleen lymphocytes and bone marrow cells, induced lacI mutants in the liver, and induced
The effects of dietary 2-acetylaminofluorene (2-AAF) on cell cycle-related proteins was studied in regenerating livers from male Wistar rats. The levels of cyclins, cyclin dependent kinases (cdks), and related proteins were studied at different times during the first cell cycle after partial hepatec