Changes in rat liver N-hydroxy-2-acetylaminofluorene aryl sulfotransferase activity at early and late stages of hepatocarcinogenesis resulting from dietary administration of 2-acetylaminofluorene

Evidence of two separate mechanisms for

Evidence of two separate mechanisms for the decrease in aryl sulfotransferase activity in rat liver during early stages of 2-acetylaminofluorene–induced hepatocarcinogenesis

✍ David P. Ringer; Boyd A. Howell; Tom R. Norton; Gary W. Woulfe; Michael W. Duffe 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 691 KB

## Abstract Enzymatic and immunohistochemical experiments were conducted to evaluate the mechanistic basis for the downregulation of the important detoxication/bioactivation enzyme aryl sulfotransferase IV (AST IV) during 2‐ acetylaminofluorene (2AAF)–induced hepatocarcinogenesis. To distinguish be