The ability of 6-ketocholestanol to increase the skin permeation of the prodrug aminolevulinic acid (5-ALA) was investigated. 6-Ketocholestanol was incorporated together with 5-ALA in four different formulations. Preparations used were a liquid solution/suspension of 5-ALA in buffer, 5-ALA in phosph
Skin permeation and stability studies of 5-aminolevulinic acid in a new gel and patch preparation
β Scribed by C. Valenta; B.G. Auner; I. Loibl
- Book ID
- 113691003
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 114 KB
- Volume
- 107
- Category
- Article
- ISSN
- 0168-3659
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Aminolevulinic acid (ALA) stability within topical formulations intended for photodynamic therapy (PDT) is poor due to dimerisation to pyrazine-2,5-dipropionic acid (PY). Most strategies to improve stability use low pH vehicles, which can cause cutaneous irritancy. To overcome this problem, a novel
## Abstract Mitochondrial oxygen tension can be measured in vivo by means of oxygenβdependent quenching of delayed fluorescence of protoporphyrin IX (PpIX). Here we demonstrate that delayed fluorescence is readily observed from skin in rat and man after topical application of the PpIX precursor 5βa