Skin irritant effects of esters of phorbol and related polyols
β Scribed by Richard J. Schmidt; Fred J. Evans
- Publisher
- Springer-Verlag
- Year
- 1980
- Tongue
- English
- Weight
- 578 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0340-5761
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The isobutane chemical ionization mass spectra of a series of 4aa-phorbol esters have been determined. Phorbol myristate acetate, a diester of phorbol, is the most potent known tumor promoter in mouse skin carcinogenesis. Several esters of the stereoisomer of phorbol have been synthesized to study t
## Abstract Previous data from twoβstage carcinogenesis studies in mouse skin demonstrated that genetic control of susceptibility to skin tumor promotion by the phorbol ester, 12βOβtetradecanoylphorbolβ13βacetate (TPA), in crosses between susceptible DBA/2J and resistant C57BL/6J mice is a multigen
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