𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Chemical ionization mass spectrometry of the tumor promoter related 4aα-phorbol esters

✍ Scribed by Jerome J. Solomon; Benjamin L. Van Duuren; Shin-Shyong Tseng

Publisher
John Wiley and Sons
Year
1978
Tongue
English
Weight
476 KB
Volume
5
Category
Article
ISSN
1076-5174

No coin nor oath required. For personal study only.

✦ Synopsis

The isobutane chemical ionization mass spectra of a series of 4aa-phorbol esters have been determined. Phorbol myristate acetate, a diester of phorbol, is the most potent known tumor promoter in mouse skin carcinogenesis. Several esters of the stereoisomer of phorbol have been synthesized to study the effect of structure and stereochemistry on tumor promotion. Conventional electron impact mass spectra of these esters gave little or no molecular weight information due to their low volatility, tendency to dehydrate and complex fragmentation to peaks in the low mass end of the spectrum. Isobutane chemical ionization mass spectrometry greatly enhanced the molecular ion region and through functional group selectivity established the identity of the various substituted esters.

📜 SIMILAR VOLUMES

Determination of the Limited Trypsinolys
Determination of the Limited Trypsinolysis Pathways of Tumor Necrosis Factor-α and Its Mutant by Electrospray Ionization Mass Spectrometry
✍ Yeoun Jin Kim; Sun-Shin Cha; Jeong-Sun Kim; Nam-Kyu Shin; Woojin Jeong; Hang-Che 📂 Article 📅 1999 🏛 Elsevier Science 🌐 English ⚖ 124 KB

## Electrospray ionization mass spectrometry (ESI-MS ) is employed to directly analyze the limited trypsinolysis products of wild-type tumor necrosis factor-␣ (wtTNF-␣) and its mutant, M3S. To determine the charge numbers of peaks of relatively small peptides in the ESI mass spectrum of a digest,

Mechanism of the formation of a dehydrat
Mechanism of the formation of a dehydrated ion by an unusual loss of oxygen at the 4′-carbonyl group of abscisic acid methyl ester in electron ionization mass spectrometry
✍ Masahiro Inomata; Nobuhiro Hirai; Naohito Takeda; Hajime Ohigashi 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 215 KB

## Abstract Methyl ester of abscisic acid (ABA), a plant hormone, gives a dehydrated ion at __m__/__z__ 260 in electron ionization mass spectrometry (EI–MS). This dehydrated ion had been considered to be derived only from the elimination of the tertiary hydroxyl group at C‐1′. We found that 34% of