✦ LIBER ✦
Spin-labeled phorbol esters and their interaction with cellular membranes. I. Synthesis of spin-labeled phorbol-12, 13-diesters and related compounds
✍ Scribed by S. Pečar; B. Sorg; M. Schara; E. Hecker
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- English
- Weight
- 410 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0009-3084
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✦ Synopsis
The synthesis of analogs of the cocarcinogen and tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) containing spin labeled acid residues in position 12 or 13 of the phorbol moiety is described. Chemical and spectroscopic characteristics of the new compounds are reported. The stability of the nitroxide groups of the spin probes and their isotropic hyperfine splittings in different solvents are determined.