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Skepinone-L is a selective p38 mitogen-activated protein kinase inhibitor

✍ Scribed by Koeberle, Solveigh C; Romir, Johannes; Fischer, Stefan; Koeberle, Andreas; Schattel, Verena; Albrecht, Wolfgang; Grütter, Christian; Werz, Oliver; Rauh, Daniel; Stehle, Thilo

Book ID: 111643352
Publisher: Nature Publishing Group
Year: 2011
Tongue: English
Weight: 371 KB
Volume: 8
Category: Article
ISSN: 1552-4450
DOI: 10.1038/nchembio.761

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## Abstract The p38 MAPKs are a family of kinases that regulate a number of cellular functions including cell migration, proliferation, and differentiation. Here, we report that p38 regulates oligodendrocyte differentiation. Inhibition of p38 with PD169316 and SB203580 prevented accumulation of pro