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Dehydroepiandrosterone negatively regulates the p38 mitogen-activated protein kinase pathway by a novel mitogen-activated protein kinase phosphatase

✍ Scribed by Kenji Ashida; Kiminobu Goto; Yue Zhao; Taijiro Okabe; Toshihiko Yanase; Ryoichi Takayanagi; Masatoshi Nomura; Hajime Nawata

Book ID
113485365
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
435 KB
Volume
1728
Category
Article
ISSN
0167-4781

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## Abstract **Background:** Cellular senescence is a state of irreversible growth arrest shown by normal cells, and has been most extensively studied in replicative senescence caused by telomere shortening. Several conditions, including oncogenic Ras over‐expression and inappropriate culture condit