Sister chromatid exchanges in human fibroblasts characterized by monosomy X
โ Scribed by J. -J. Cassiman; P. Vercauteren; H. Van den Berghe
- Publisher
- Springer
- Year
- 1985
- Tongue
- English
- Weight
- 149 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0340-6717
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
This study examined the effect of pyrimethamine (PYR) on sister chromatid exchanges (SCEs) in human lymphocytes. PYR is a folic acid antagonist used for the treatment of malaria and toxoplasmosis. PYR was added to peripheral blood lymphocyte cultures at three different doses: 0.05, 0.1, and 0.2 mg/m
## Abstract The frequency of sister chromatid exchange (SCE) in WIโ38 cells was estimated by the 5โbromodeoxyuridine (BrdUrd)โdye technique after one hour's exposure to cyclophosphamide (CY), NโmethylโNโฒโnitroโNโnitrosoguanidine (MNNG), 4โnitroquinolineโ1โoxide (4NQO), and maleic hydrazide (MH) wit
Human female blood cultures were labeled with BrdU for detecting sister chromatid exchanges (SCEs) by the Hoechst 33258 fluorescence technique. Late labeling with 3H-thymidine and autoradiography allowed the identification of the late replicating X. The mean number of SCEs in the cells was 13. The i
Cocultivation of fibroblast cells from a male patient with Bloom syndrome (BS) and a female control reduced the rate of sister chromatid exchanges in the BS cells from a mean of 54 SCE per metaphase (range 42--65) to 41 (range 24--59). Medium used to culture control cells for 48 h also reduced the r