✦ LIBER ✦

Sister chromatid exchange induction in two cell lines

✍ Scribed by Mitchell, Gillian A. ;Meher-Homji, K. M. ;Baker, R. S. U.

Publisher: Wiley (John Wiley & Sons)
Year: 1982
Weight: 186 KB
Volume: 4
Category: Article
ISSN: 0192-2521
DOI: 10.1002/em.2860040309

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Sister chromatid exchange (SCE) induction by the procarcinogen benzo (a)‐pyrene (BP) was studied using two established cell lines. Chinese hamster ovary (CHO) and Chinese hamster lung (Don) cells were exposed to varying concentrations of BP in the presence and absence of a rat liver metabolizing system. Results showed a significant difference in the abilities of the two cell lines to induce SCE in the absence of liver homogenate. These experiments demonstrate that Don cells are capable of generating active metabolites from biologically inactive procarcinogens presumably due to an inherent metabolizing system which is deficient or absent in CHO cells.

📜 SIMILAR VOLUMES

Sister chromatid exchange in cell lines

Sister chromatid exchange in cell lines from malignant lymphomas (lymphoma lines)

✍ Christa Fonatsch; M. Schaadt; V. Diehl 📂 Article 📅 1979 🏛 Springer 🌐 English ⚖ 547 KB

The frequency of sister chromatid exchanges (SCEs) was studied in cells from three freshly established lymphoma lines, derived from two patients with Hodgkin's disease and one patient with non-Hodgkin lymphoma. These values were compared to SCE rates found in cells from two long-established lymphoma

Different effects of mutagens on sister

Different effects of mutagens on sister chromatid exchange induction in three chinese hamster cell lines

✍ Mehnert, Karl ;Vogel, Walther ;Benz, Reiner ;Speit, Günter 📂 Article 📅 1984 🏛 Wiley (John Wiley & Sons) ⚖ 658 KB

Sister chromatid exchanges inDrosophila

Sister chromatid exchanges inDrosophila melanogastercell lines in vitro

✍ Silvana Faccio Dolfini 📂 Article 📅 1978 🏛 Springer 🌐 English ⚖ 847 KB

Induction of sister chromatid exchanges

Induction of sister chromatid exchanges in murine colonic tissue

✍ Couch, David B. ;Gingerich, John D. ;Stuart, Earl ;Heddle, John A. 📂 Article 📅 1986 🏛 Wiley (John Wiley & Sons) ⚖ 508 KB

Ultrasonic induction of sister chromatid

Ultrasonic induction of sister chromatid exchanges in human lymphocytes

✍ Michael Haupt; Alice O. Martin; Joe Leigh Simpson; M. Anwaruddin Iqbal; Sherman 📂 Article 📅 1981 🏛 Springer 🌐 English ⚖ 626 KB

Characterization of sister chromatid exc

Characterization of sister chromatid exchange induction by hydrogen peroxide

✍ Speit, G. ;Vogel, W. ;Wolf, M. 📂 Article 📅 1982 🏛 Wiley (John Wiley & Sons) ⚖ 465 KB

Hydrogen peroxide (H,O,) induces SCEs in V-79 Chinese hamster cells. The incorporation of BrdUrd sensitizes the cells to the action of H,O,, but damage leading to the formation of SCEs can also be induced in DNA not substitued with BrdUrd. Catalase leads to a complete reduction of the SCE-producing