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Sister chromatid exchange in PH1-positive chronic myelocytic leukemia

✍ Scribed by Dr. Reinhard Becher; Carl G. Schmidt; Gabriele Theis; Dieter K. Hossfeld

Publisher: John Wiley and Sons
Year: 1979
Tongue: French
Weight: 294 KB
Volume: 24
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910240602

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✦ Synopsis

Abstract

The sister chromatid exchange (SCE) frequency in bone‐marrow cells of 12 untreated patients with chronic myelocytic leukemia (CML) was analysed and compared with the SCE frequency in bone‐marrow cells of nine healthy persons. In normal persons the SCE ranged from 3.64 to 5.15 per cell. In CML patients the SCE was significantly lower, ranging from 2.32 to 3.44 per cell. The differences found were unrelated to patients' age and contraction state of the chromosomes. It is suggested that the leukemic process could account for the low SCE rate.

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