Single nucleotide variation in exon 11 of canine BRCA2 in healthy and cancerous mammary tissue
โ Scribed by Wei-Li Hsu; Yi-Hsin Huang; Tien-Jye Chang; Min-Liang Wong; Shih-Chieh Chang
- Book ID
- 113939600
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 499 KB
- Volume
- 184
- Category
- Article
- ISSN
- 1090-0233
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## Abstract Germline mutations in the BRCA1 and BRCA2 genes are associated with a significantly increased lifetime risk for developing breast and/or ovarian cancer. However, incomplete penetrance and substantial variability in age of disease onset among carriers of the same mutation suggests the in
Studies on mutations of BRCA1 gene in Oriental populations, especially in Chinese are sparse. To evaluate the contribution of BRCA1 mutations to sporadic breast cancer in Chinese, mutations in exon 11 from nucleotide positions 3533 to 3682(U14680), a highly variable region of BRCA1 gene, were screen