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Single Channel Studies and Kinetic Modeling of an Inactivation Deficient Voltage-Gated Sodium Channel

โœ Scribed by Goldschen-Ohm, Marcel P.; Capes, Deborah; Chanda, Baron

Book ID
122270440
Publisher
Biophysical Society
Year
2012
Tongue
English
Weight
93 KB
Volume
102
Category
Article
ISSN
0006-3495

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## Abstract The sodium channel gene __Scn8a__ encodes the channel Na~V~1.6, which is widely distributed in the central and peripheral nervous system. Na~V~1.6 is the major channel at the nodes of Ranvier in myelinated axons. Mutant alleles of mouse __Scn8a__ result in neurological disorders includi