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Simvastatin Suppresses Self-Renewal of Mouse Embryonic Stem Cells by Inhibiting RhoA Geranylgeranylation

✍ Scribed by Mi-Hee Lee; Yee Sook Cho; Yong-Mahn Han


Book ID
119923605
Publisher
AlphaMed Press
Year
2007
Tongue
English
Weight
712 KB
Volume
25
Category
Article
ISSN
1066-5099

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Cdk1 is required for the self-renewal of
✍ Wei Wei Zhang; Xiao Jie Zhang; Hui Xian Liu; Jie Chen; Yong Hong Ren; Deng Gao H πŸ“‚ Article πŸ“… 2011 πŸ› John Wiley and Sons 🌐 English βš– 277 KB

## Abstract Cyclin‐dependent kinase 1 (Cdk1) is indispensible for the early development of the embryo. However, its role in maintaining the undifferentiated state of the embryonic stem (ES) cells remains unknown. In this study, we dissected the function of Cdk1 in mouse ES cells by RNA‐interference