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Suppression of SHP-2 and ERK Signalling Promotes Self-Renewal of Mouse Embryonic Stem Cells

✍ Scribed by Tom Burdon; Craig Stracey; Ian Chambers; Jennifer Nichols; Austin Smith

Book ID
115598087
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
501 KB
Volume
210
Category
Article
ISSN
0012-1606

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## Abstract Cyclin‐dependent kinase 1 (Cdk1) is indispensible for the early development of the embryo. However, its role in maintaining the undifferentiated state of the embryonic stem (ES) cells remains unknown. In this study, we dissected the function of Cdk1 in mouse ES cells by RNA‐interference