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Role of Lef1 in sustaining self-renewal in mouse embryonic stem cells

✍ Scribed by Chen Huang; Dajiang Qin

Book ID
118651320
Publisher
Elsevier
Year
2010
Tongue
Chinese
Weight
981 KB
Volume
37
Category
Article
ISSN
1673-8527

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## Abstract Cyclin‐dependent kinase 1 (Cdk1) is indispensible for the early development of the embryo. However, its role in maintaining the undifferentiated state of the embryonic stem (ES) cells remains unknown. In this study, we dissected the function of Cdk1 in mouse ES cells by RNA‐interference