Opposing microRNA families regulate self-renewal in mouse embryonic stem cells
β Scribed by Melton, Collin; Judson, Robert L.; Blelloch, Robert
- Book ID
- 109898794
- Publisher
- Nature Publishing Group
- Year
- 2010
- Tongue
- English
- Weight
- 89 KB
- Volume
- 464
- Category
- Article
- ISSN
- 0028-0836
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## Abstract Cyclinβdependent kinase 1 (Cdk1) is indispensible for the early development of the embryo. However, its role in maintaining the undifferentiated state of the embryonic stem (ES) cells remains unknown. In this study, we dissected the function of Cdk1 in mouse ES cells by RNAβinterference
## Abstract Mouse embryonic stem (mES) cells are pluripotent cells that can be propagated in vitro with leukemia inhibitory factor (LIF) and serum. Intracellular signaling by LIF is principally mediated by activation of STATβ3, although additional pathways for selfβrenewal have been described. Here