Human embryonic stem cells (hESCs), derived from the inner cell mass (ICM) of the blastocyst, have the capacity for longterm undifferentiated growth in culture and the theoretical potential to differentiate into all somatic cell types. [1] These hESCs offer not only a model system for human developm
Deconstructing human embryonic stem cell cultures: niche regulation of self-renewal and pluripotency
β Scribed by Morag H. Stewart; Sean C. Bendall; Mickie Bhatia
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 441 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0946-2716
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Human embryonic stem cells (hESCs), derived from the inner cell mass (ICM) of the blastocyst, have the capacity for longterm undifferentiated growth in culture and the theoretical potential to differentiate into all somatic cell types. [1] These hESCs offer not only a model system for human developm
## Abstract Embryonic stem cells (ES cells) are derived from inner cell mass (ICM). The selfβrenewal and pluripotency are the main specificities of ES cells, which are likely to reveal a deeper understanding of human cellular biology and which are considered to be promising sources for cell therapy
## Abstract Human embryonic stem cells (hESCs) have the potential to differentiate into all cell types in the body and hold great promise for regenerative medicine; however, largeβscale expansion of undifferentiated hESCs remains a major challenge. Selfβrenewal of hESCs requires culturing these cel