## Abstract Hodgkin's and Reed/Sternberg (HRS) cells, the tumour cells in classical Hodgkin's lymphoma (HL), represent transformed B cells in nearly all cases. The detection of destructive somatic mutations in the rearranged immunoglobulin (Ig) genes of HRS cells in classical HL indicated that they
Simvastatin-dependent apoptosis in Hodgkin's lymphoma cells and growth impairment of human Hodgkin's tumors in vivo
β Scribed by von Tresckow, B.; von Strandmann, E. P.; Sasse, S.; Tawadros, S.; Engert, A.; Hansen, H. P.
- Book ID
- 126274853
- Publisher
- Ferrata Storti Foundation
- Year
- 2007
- Tongue
- Italian
- Weight
- 765 KB
- Volume
- 92
- Category
- Article
- ISSN
- 0390-6078
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We re-appraised the cell renewal pattern in Hodgkin's disease (HD), considering that most, though not all, Hodgkinf Reed- ## Sternberg (H-RS) cells exhibit abortive mitoses and that a substantial fraction of these exhibits DNA damage suggestive of imminent or actual cell death. Using combined immu
Inactivation of the retinoblastoma susceptibility (Rb) gene has been observed in various cancers. Nevertheless, in several cancer cases, including non-Hodgkin's lymphoma, previous investigations showed that the Rb gene product (pRb) was abundantly expressed with varying degree. Here we report the TH