Retinoblastoma protein expressed in human non-Hodgkin's lymphoma cells generates resistance against radiation-induced apoptosis
✍ Scribed by Ishii, Hideshi; Igarashi, Tadahiko; Saito, Toshiyuki; Nakano, Takashi; Mori, Masahiko; Ohyama, Harumi; Miyamoto, Tadaaki; Saito, Yasushi; Oh, Hakumei
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 138 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0361-8609
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✦ Synopsis
Inactivation of the retinoblastoma susceptibility (Rb) gene has been observed in various cancers. Nevertheless, in several cancer cases, including non-Hodgkin's lymphoma, previous investigations showed that the Rb gene product (pRb) was abundantly expressed with varying degree. Here we report the THS-SP1.1 cell line isolated from non-Hodgkin's lymphoma. The THS-SP1.1 cells abundantly expressed pRb and showed resistance against radiation-induced apoptosis. Culture with the antisense phosphorothioate oligonucleotide complementary to the Rb gene augmented the apoptosis of THS-SP1.1 cells after radiation, whereas the control oligonucleotides did not. These data showed that pRb abundantly expressed in the lymphoma cells inhibited radiation-induced apoptosis. Am