Simultaneous Separation and Determination of Isosorbide Dinitrate and Isosorbide 5-Mononitrate in Human Plasma by LC–MS–MS
✍ Scribed by Hohyun Kim; Jae-Yong Lee; Ki-Seob Song; Young-Hwan Seo; So-Young Park; Kyeong-Ho Kim; Hyun Dong Je; Sang Beom Han; Ji Hoon Jeong
- Book ID
- 111791911
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 561 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0009-5893
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0 A previously described electron-capture CLC method for determination of isosorbide dinitrate in human plasma was adapted for the simultaneous determination of isosorbide dinitrate, isosorbide 2mononitrate, and isosorbide 5-mononitrate using a capillary column. Quantitation was done with two intern
The concentrations of isosorbide dinitrate (ISDN), isosorbide-5-mononitrate (IS-5-MN) and isosorbide-2-mononitrate (IS-2-MN) were determined in plasma (PL), saphenous vein wall (SV) and pectoral muscle (PM) from 8 patients undergoing coronary bypass surgery. The patients were pretreated for 2 days w