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LC Determination of Isosorbide-5-Mononitrate in Human Plasma

✍ Scribed by Himanshu S. Karmalkar; Mohan M. Metku; Milind S. Bagul; Asmita C. Nimkar; Rajen D. Shah

Book ID
111791428
Publisher
Springer
Year
2009
Tongue
English
Weight
292 KB
Volume
69
Category
Article
ISSN
0009-5893

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Isosorbide 5-mononitrate pharmacokinetic
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## Abstract When isosorbide 5‐mononitrate was intravenously infused at a rate of 4 mg h ^βˆ’1^ for 2.5 h to five human subjects, its concentrations in plasma increased slowly to 185 ng ml^βˆ’1^ Β± 5 per cent C.V. at 2.5 h and a steady‐state plasma level was not reached during the infusion. When the infu