Simultaneous determination of isosorbide dinitrate and its mononitrates in human plasma by capillary column GLC

✍ Scribed by M. T. Rosseel; M. G. Bogaert

• Publisher: John Wiley and Sons
• Year: 1979
• Tongue: English
• Weight: 223 KB
• Volume: 68
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600680542

✦ Synopsis

0 A previously described electron-capture CLC method for determination of isosorbide dinitrate in human plasma was adapted for the simultaneous determination of isosorbide dinitrate, isosorbide 2mononitrate, and isosorbide 5-mononitrate using a capillary column. Quantitation was done with two internal standards. The lower limits of detection were approximately 0.5 ng/ml of plasma for isosorbide dinitrate. 2 ng/ml for isosorbide 2-mononitrate, and 20 ng/ml for isosorbide 5monon i trate.

Keyphrases 0 Isosorbide dinitrate-and mononitrates, simultaneous electron-capture CLC analysis, human plasma 0 GLC, electron capture-analysis, isosorbide dinitrate and mononitrates, human plasma lsosorbide mononitrates-and dinitrate, simultaneous electron-capture GLC analysis, human plasma