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Simultaneous quantitative determination of paracetamol and its glucuronide conjugate in human plasma and urine by liquid chromatography coupled to electrospray tandem mass spectrometry: Application to a clinical pharmacokinetic study

โœ Scribed by Qin-you Tan; Rong-hua Zhu; Huan-de Li; Feng Wang; Miao Yan; Li-bo Dai

Book ID
113687686
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
994 KB
Volume
893-894
Category
Article
ISSN
1873-376X

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## Abstract A rapid and sensitive LC/MS/MS assay was developed and validated for the determination of clopidogrel in human plasma. Clopidogrel was extracted by single liquidโ€“liquid extraction with pentane, and chromatographic separations were achieved on a C~18~ column. The method was validated to