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Determination of imidol hydrochloride in human plasma and urine by high-performance liquid chromatography–tandem mass spectrometry and its application to clinical pharmacokinetic study

✍ Scribed by Zhengyuan Shi; Kaishun Bi; Yang Li; Xin Hu; Kexin Li; Ping Gong; Xiaohui Chen

Book ID: 112013368
Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 206 KB
Volume: 26
Category: Article
ISSN: 0269-3879
DOI: 10.1002/bmc.1687

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## Abstract A rapid and sensitive LC/MS/MS assay was developed and validated for the determination of clopidogrel in human plasma. Clopidogrel was extracted by single liquid–liquid extraction with pentane, and chromatographic separations were achieved on a C~18~ column. The method was validated to