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Simultaneous determination of the camptothecin analogue CPT-11 and its active metabolite SN-38 by high-performance liquid chromatography: application to plasma pharmacokinetic studies in cancer patients

✍ Scribed by Iman Barilero; Daniel Gandia; Jean-Pierre Armand; Anne Mathieu-Boué; Micheline Ré; Alain Gouyette; Guy G. Chabot


Book ID
107996933
Publisher
Elsevier Science
Year
1992
Weight
546 KB
Volume
575
Category
Article
ISSN
0378-4347

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A sensitive and stereoselective high-performance liquid chromatographic assay for the quantitative determination of the analgesic tramadol and Odemethyltramadol, an active metabolite, is described in this work. Ketamine was used as internal standard. The assay involved a single tert-butymethylether