𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Reversed-phase high-performance liquid chromatographic method for the simultaneous quantitation of the carboxylate and lactone forms of the camptothecin derivative irinotecan, CPT-11, and its metabolite SN-38 in plasma

✍ Scribed by Laurent P. Rivory; Jacques Robert


Publisher
Elsevier Science
Year
1994
Weight
698 KB
Volume
661
Category
Article
ISSN
0378-4347

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


High-Performance Liquid Chromatographic
✍ Gary Boyd; John F. Smyth; Duncan I. Jodrell; Jeffrey Cummings πŸ“‚ Article πŸ“… 2001 πŸ› Elsevier Science 🌐 English βš– 97 KB

## Analysis of camptothecins in biologic media is hampered by chemical hydrolysis of the parent lactone (form I) to an inactive hydroxy acid (form II). A solidphase extraction (SPE) method utilizing C2 -bonded silica particles (100 mg, 1 ml) is presented for simultaneous determination of forms I a

High-performance liquid chromatographic
✍ Nobumitsu Hanioka; Hideto Jinno; Tetsuji Nishimura; Masanori Ando; Shogo Ozawa; πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 116 KB πŸ‘ 1 views

## Abstract A simple and sensitive assay for glucuronidation activity of 7‐ethyl‐10‐hydroxycamptothecin (SN‐38), the active metabolite of irinotecan (CPT‐11), in human liver microsomes by high‐performance liquid chromatography (HPLC) with fluorescence detection is reported. The method was validated

A high-performance liquid chromatographi
✍ Anne T. Wu; Ian J. Massey; Stanley Kushinsky πŸ“‚ Article πŸ“… 1984 πŸ› John Wiley and Sons 🌐 English βš– 395 KB πŸ‘ 1 views

## Acknowledgements The authors thank the Upjohn Co., Kalamazm, Mich.. for the generous supplies of tolbutamide. One of the authors (P. M.) gratefully acknowledges the financial support of the Delegation Generale Recherche Sciences et Techniques (Paris, France).

High-Performance Liquid Chromatographic
✍ V. R. Shah; N. R. Srinivas; D. A. Campbell; S. Mantha; G. Duncan; A. Schuster; D πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 383 KB πŸ‘ 2 views

A specific, accurate, precise, and reproducible High-performance liquid chromatographic-Ultraviolet (HPLC-W) method was developed for the simultaneous quantitation of BMS-181101 (I), a new antidepressant, and its putative metabolites, 6'-hydroxy (11) and 7'-hydroxy (111) of BMS-181101 in rat and mon