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High-performance liquid chromatographic assay for simultaneous determination of tramadol and its active metabolite in human plasma. Application to pharmacokinetic studies

✍ Scribed by M. A. Campanero; B. Calahorra; E. García-Quetglás; M. Escolar; J. Honorato


Publisher
Springer
Year
1998
Tongue
English
Weight
494 KB
Volume
48
Category
Article
ISSN
0009-5893

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Enantiomeric separation of tramadol and
✍ M.A. Campanero; B. Calahorra; M. Valle; I.F. Troconiz; J. Honorato 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 131 KB 👁 2 views

A sensitive and stereoselective high-performance liquid chromatographic assay for the quantitative determination of the analgesic tramadol and Odemethyltramadol, an active metabolite, is described in this work. Ketamine was used as internal standard. The assay involved a single tert-butymethylether