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Simultaneous determination of L-702,007, a HIV-1 reverse transcriptase inhibitor, and its 6-hydroxy metabolite in human plasma by column-switching high-performance liquid chromatography with fluorescence detection

✍ Scribed by E.J. Woolf; B. Matuszewski

Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
412 KB
Volume
729
Category
Article
ISSN
1873-3778

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We report the development of a simple, economical and reliable chromatographic method for the simultaneous determination of six HIV protease inhibitors (PIs; amprenavir, indinavir, lopinavir, nelfinavir, ritonavir and saquinavir), the active metabolite of nelfinavir (M8) and the non-nucleoside rever